mangostanin [Ligand Id: 13468] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL561643 (9-Hydroxycalabaxanthone, Mangostanin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fatty acid synthase/Fatty acid synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327] | ||||||||
| ChEMBL | Inhibition of FAS | B | 4.39 | pIC50 | 40640 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6045-6047 [PMID:20817450] |
| nuclear factor kappa B subunit 1/Nuclear factor NF-kappa-B p105 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3251] [GtoPdb: 3281] [UniProtKB: P19838] | ||||||||
| ChEMBL | Inhibition of p50 after 1 hr by ELISA | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Nat Prod (2009) 72: 2028-2031 [PMID:19839614] |
| RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B p65 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5533] [GtoPdb: 3280] [UniProtKB: Q04206] | ||||||||
| ChEMBL | Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISA | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Nat Prod (2009) 72: 2028-2031 [PMID:19839614] |
| phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
| ChEMBL | Inhibition of human PDE4D2 (86 to 413 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | B | 6.38 | pIC50 | 420 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| ChEMBL | Inhibition of PDE4D2 (86-413) (unknown origin) expressed in Escherichia coli BL21 assessed as using [3H]-cAMP as substrate measured for 15 mins by liquid scintillation counting analysis | B | 6.38 | pIC50 | 420 | nM | IC50 | J Med Chem (2021) 64: 13736-13751 [PMID:34520193] |
| ChEMBL | Inhibition of recombinant PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation method | B | 6.38 | pIC50 | 420 | nM | IC50 | Eur J Med Chem (2022) 242: 114631-114631 [PMID:35985255] |
| GtoPdb | Inhibition of PDE4D2 | - | 6.38 | pIC50 | 420 | nM | IC50 | J Med Chem (2020) 63: 3370-3380 [PMID:32115956] |
| Sialidase in Clostridium perfringens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5189] [UniProtKB: P10481] | ||||||||
| ChEMBL | Competitive inhibition of Clostridium perfringens neuraminidase by fluorimetry | B | 5.23 | pKi | 5900 | nM | Ki | Bioorg Med Chem (2010) 18: 6258-6264 [PMID:20696581] |
| ChEMBL | Inhibition of Clostridium perfringens neuraminidase by fluorimetry | B | 4.7 | pIC50 | 20100 | nM | IC50 | Bioorg Med Chem (2010) 18: 6258-6264 [PMID:20696581] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
