14-Deoxy-11,12-didehydroandrographolide [Ligand Id: 13464] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL361568 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV3/Transient receptor potential cation channel subfamily V member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5522] [GtoPdb: 509] [UniProtKB: Q8NET8] | ||||||||
| ChEMBL | Inhibition of TRPV3 in human HaCaT cells assessed as reduction in carvacrol-induced calcium influx measured for 60 mins by Fluo-4-AM dye based fluorescence assay | B | 6.07 | pIC50 | 850 | nM | IC50 | J Nat Prod (2024) 87: 1852-1859 [PMID:38961616] |
| ChEMBL | Inhibition of human TRPV3 expressed in CHO cells assessed as reduction in 2-APB induced channel current at +80 mV by whole-cell patch clamp electrophysiology | B | 6.1 | pIC50 | 800 | nM | IC50 | J Nat Prod (2024) 87: 1852-1859 [PMID:38961616] |
| GtoPdb | Determined as inhibition of 2-APB channel activation in a fluorescent calcium assay; at +80 mV | - | 6.1 | pIC50 | 800 | nM | IC50 | J Nat Prod (2024) 87: 1852-1859 [PMID:38961616] |
| ChEMBL | Inhibition of human TRPV3 expressed in CHO cells assessed as reduction in 2-APB induced channel current at -80 mV by whole-cell patch clamp electrophysiology | B | 6.25 | pIC50 | 560 | nM | IC50 | J Nat Prod (2024) 87: 1852-1859 [PMID:38961616] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
