ML211 [Ligand Id: 13415] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1903566
  • lysophospholipase 1/Acyl-protein thioesterase 1 in Human [ChEMBL: CHEMBL1681631] [GtoPdb: 3290] [UniProtKB: O75608]
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  • lysophospholipase 2/Acyl-protein thioesterase 2 in Human [ChEMBL: CHEMBL1932891] [GtoPdb: 3291] [UniProtKB: O95372]
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  • Alpha/beta hydrolase domain-containing protein 11 in Human [ChEMBL: CHEMBL2189134] [UniProtKB: Q8NFV4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
lysophospholipase 1/Acyl-protein thioesterase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681631] [GtoPdb: 3290] [UniProtKB: O75608]
ChEMBL Inhibition of human APT1 B 7.77 pIC50 17 nM IC50 Medchemcomm (2014) 5: 268-276 [PMID:25558349]
GtoPdb - - 7.77 pIC50 17 nM IC50 Medchemcomm (2014) 5: 268-276 [PMID:25558349]
lysophospholipase 2/Acyl-protein thioesterase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932891] [GtoPdb: 3291] [UniProtKB: O95372]
GtoPdb - - 7.52 pIC50 30 nM IC50 Medchemcomm (2014) 5: 268-276 [PMID:25558349]
ChEMBL Inhibition of human APT2 B 7.52 pIC50 30 nM IC50 Medchemcomm (2014) 5: 268-276 [PMID:25558349]
Alpha/beta hydrolase domain-containing protein 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189134] [UniProtKB: Q8NFV4]
ChEMBL Inhibition of ABHD11 (unknown origin) B 7.52 pIC50 <30 nM IC50 Medchemcomm (2014) 5: 268-276 [PMID:25558349]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]