Palmostatin B [Ligand Id: 13414] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1673415 (Palmostatin B) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| lysophospholipase 1/Acyl-protein thioesterase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681631] [GtoPdb: 3290] [UniProtKB: O75608] | ||||||||
| ChEMBL | Inhibition of APT1 | B | 6.17 | pIC50 | 670 | nM | IC50 | Bioorg Med Chem (2011) 19: 1376-1380 [PMID:21129981] |
| ChEMBL | Inhibition of APT1 (unknown origin) | B | 8.27 | pIC50 | 5.4 | nM | IC50 | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| GtoPdb | - | - | 8.27 | pIC50 | 5.4 | nM | IC50 | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| lysophospholipase 2/Acyl-protein thioesterase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932891] [GtoPdb: 3291] [UniProtKB: O95372] | ||||||||
| ChEMBL | Inhibition of APT2 (unknown origin) | B | 7.47 | pKi | 34 | nM | Ki | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| GtoPdb | - | - | 7.42 | pIC50 | 37.7 | nM | IC50 | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| ChEMBL | Inhibition of APT2 (unknown origin) | B | 7.42 | pIC50 | 37.7 | nM | IC50 | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| Protein BAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6168] [UniProtKB: O95870] | ||||||||
| ChEMBL | Inhibition of ABHD16A (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | ACS Med Chem Lett (2018) 9: 1269-1273 [PMID:30613338] |
| ChEMBL | Inhibition of human ABHD16A expressed in HEK293 cells preincubated for 30 mins followed by 1-LG substrate addition and measured after 90 to 120 mins by fluorometric assay | B | 7 | pIC50 | 99 | nM | IC50 | ACS Med Chem Lett (2018) 9: 1269-1273 [PMID:30613338] |
| ChEMBL | Reversible inhibition of human ABHD16A expressed in HEK293 cells preincubated for 30 mins followed by 40 fold compound dilution and subsequent 1-LG substrate addition and measured at 30 mins time interval for 120 mins by fluorometric assay | B | 7.24 | pIC50 | 57 | nM | IC50 | ACS Med Chem Lett (2018) 9: 1269-1273 [PMID:30613338] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
