ML348 [Ligand Id: 13412] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL600764 (GNF-Pf-1127) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| lysophospholipase 1/Acyl-protein thioesterase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681631] [GtoPdb: 3290] [UniProtKB: O75608] | ||||||||
| GtoPdb | - | - | 6.52 | pKi | 300 | nM | Ki | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| ChEMBL | Inhibition of APT1 (unknown origin) by FluPol-ABPP assay | B | 6.52 | pKi | 300 | nM | Ki | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| lysophospholipase 2/Acyl-protein thioesterase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932891] [GtoPdb: 3291] [UniProtKB: O95372] | ||||||||
| ChEMBL | Inhibition of APT2 (unknown origin) by FluPol-ABPP assay | B | 5 | pKi | >10000 | nM | Ki | Medchemcomm (2014) 5: 268-276 [PMID:25558349] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | F | 5 | pEC50 | >10000 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | F | 5.39 | pEC50 | 4040 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
