ChEMBL ligand: CHEMBL2148108
protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] There should be some charts here, you may need to enable JavaScript!
protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] There should be some charts here, you may need to enable JavaScript!
protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] There should be some charts here, you may need to enable JavaScript!
protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] There should be some charts here, you may need to enable JavaScript!
protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] There should be some charts here, you may need to enable JavaScript!
protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] There should be some charts here, you may need to enable JavaScript!
protein kinase C theta/Protein kinase C theta in Human [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL	Inhibition of [3H]PDBu binding to PKCalpha C1A domain	B	8.33	pKi	4.7	nM	Ki	J Med Chem (2012) 55: 5614-5626 [PMID:22625994]
GtoPdb	Binding affinity for the C1A domain of PKCα, determined by inhibition of [3H]PDBu binding	-	8.33	pKi	4.7	nM	Ki	J Med Chem (2012) 55: 5614-26 [PMID:22625994]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
GtoPdb	Binding affinity for the C1A domain of PKCβ, determined by inhibition of [3H]PDBu binding	-	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 5614-26 [PMID:22625994]
ChEMBL	Inhibition of [3H]PDBu binding to PKCbeta C1A domain	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 5614-5626 [PMID:22625994]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL	Inhibition of [3H]PDBu binding to PKCdelta-C1A domain peptide (unknown origin)	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2013) 21: 2695-2702 [PMID:23582444]
ChEMBL	Inhibition of [3H]PDBu binding to PKCdelta C1B domain	B	9.34	pKi	0.46	nM	Ki	J Med Chem (2012) 55: 5614-5626 [PMID:22625994]
GtoPdb	Binding affinity for the C1B domain of PKCδ, determined by inhibition of [3H]PDBu binding	-	9.34	pKi	0.46	nM	Ki	J Med Chem (2012) 55: 5614-26 [PMID:22625994]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL	Inhibition of [3H]PDBu binding to PKCepsilon C1B domain	B	8.7	pKi	2	nM	Ki	J Med Chem (2012) 55: 5614-5626 [PMID:22625994]
GtoPdb	Binding affinity for the C1B domain of PKCε, determined by inhibition of [3H]PDBu binding	-	8.7	pKi	2	nM	Ki	J Med Chem (2012) 55: 5614-26 [PMID:22625994]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL	Inhibition of [3H]PDBu binding to PKCeta C1B domain	B	9.35	pKi	0.45	nM	Ki	J Med Chem (2012) 55: 5614-5626 [PMID:22625994]
GtoPdb	Binding affinity for the C1B domain of PKCη, determined by inhibition of [3H]PDBu binding	-	9.35	pKi	0.45	nM	Ki	J Med Chem (2012) 55: 5614-26 [PMID:22625994]
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL	Inhibition of [3H]PDBu binding to PKCgamma C1A domain	B	8.26	pKi	5.5	nM	Ki	J Med Chem (2012) 55: 5614-5626 [PMID:22625994]
GtoPdb	Binding affinity for the C1A domain of PKCγ, determined by inhibition of [3H]PDBu binding	-	8.26	pKi	5.5	nM	Ki	J Med Chem (2012) 55: 5614-26 [PMID:22625994]
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
ChEMBL	Inhibition of [3H]PDBu binding to PKCtheta C1B domain	B	9.27	pKi	0.54	nM	Ki	J Med Chem (2012) 55: 5614-5626 [PMID:22625994]
GtoPdb	Binding affinity for the C1B domain of PKCθ, determined by inhibition of [3H]PDBu binding	-	9.27	pKi	0.54	nM	Ki	J Med Chem (2012) 55: 5614-26 [PMID:22625994]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]