JNJ-6204 [Ligand Id: 13345] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5081774 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646] | ||||||||
| ChEMBL | AMPKalpha2(h) Kinase panel | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe JNJ-6204 |
| casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| ChEMBL | CK1alpha(h) Kinase panel | B | 6.38 | pIC50 | 419 | nM | IC50 | Data for DCP probe JNJ-6204 |
| ChEMBL | Inhibition of CK1 alpha (unknown origin) | B | 6.39 | pIC50 | 410 | nM | IC50 | ACS Med Chem Lett (2024) 15: 486-492 [PMID:38628796] |
| casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| ChEMBL | PER2 translocation whole cell functional assay | F | 6.27 | pIC50 | 542 | nM | IC50 | Data for DCP probe JNJ-6204 |
| ChEMBL | BRET whole cell binding assay | B | 7.14 | pIC50 | 72 | nM | IC50 | Data for DCP probe JNJ-6204 |
| GtoPdb | Potency determined in a nanoBRET cellular competition binding assay- this value is for the non-deuterated analogue (compound 15) | - | 7.21 | pIC50 | 62 | nM | IC50 | ACS Med Chem Lett (2024) 15: 486-492 [PMID:38628796] |
| ChEMBL | CK1delta(h) Kinase panel | B | 8.4 | pIC50 | 4 | nM | IC50 | Data for DCP probe JNJ-6204 |
| casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
| ChEMBL | CK1epsilon(h) Kinase panel | B | 6.86 | pIC50 | 137 | nM | IC50 | Data for DCP probe JNJ-6204 |
| ChEMBL | ADP-Glo | B | 6.86 | pIC50 | 137 | nM | IC50 | Data for DCP probe JNJ-6204 |
| ChEMBL | Inhibition of CK1 epsilon (unknown origin) | B | 6.96 | pIC50 | 110 | nM | IC50 | ACS Med Chem Lett (2024) 15: 486-492 [PMID:38628796] |
| colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| ChEMBL | Fms(h) Kinase panel | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe JNJ-6204 |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | SAPK2a(h) Kinase panel | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe JNJ-6204 |
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | SAPK2b(h) Kinase panel | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe JNJ-6204 |
| Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1] | ||||||||
| ChEMBL | NDR2(h) Kinase panel | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe JNJ-6204 |
| doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568] | ||||||||
| ChEMBL | DCAMKL2(h) Kinase panel | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe JNJ-6204 |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | TGFBR1(h) Kinase panel | B | 5 | pIC50 | >10000 | nM | IC50 | Data for DCP probe JNJ-6204 |
| TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5] | ||||||||
| ChEMBL | TNIK(h) Kinase panel | B | 5.77 | pIC50 | 1700 | nM | IC50 | Data for DCP probe JNJ-6204 |
| ChEMBL | Inhibition of TNIK (unknown origin) | B | 5.77 | pIC50 | 1700 | nM | IC50 | ACS Med Chem Lett (2024) 15: 486-492 [PMID:38628796] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
