Sanglifehrin A [Ligand Id: 13322] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL410807 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| peptidylprolyl isomerase A/Cyclophilin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1949] [GtoPdb: 2751] [UniProtKB: P62937] | ||||||||
| GtoPdb | - | - | 8.48 | pKd | 3.3 | nM | Kd | J Med Chem (2018) 61: 9473-9499 [PMID:30074795] |
| ChEMBL | Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) after 30 mins by TR-FRET assay | B | 8.48 | pKd | 3.3 | nM | Kd | J Med Chem (2018) 61: 9473-9499 [PMID:30074795] |
| GtoPdb | Competitive inhibition of cylosporin A binding in a cell-free assay | - | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1609-12 [PMID:11412991] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
