ralometostat [Ligand Id: 13320] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein arginine methyltransferase 5 in Human [GtoPdb: 1256] [UniProtKB: O14744] | ||||||||
| GtoPdb | Affinity for apoPRMT5 | - | 8.72 | pKd | 1.9 | nM | Kd | J Med Chem (2024) 67: 6064-6080 [PMID:38595098] |
| GtoPdb | Affinity for MTA-PRMT5 complex | - | 9.52 | pKd | 0.3 | nM | Kd | J Med Chem (2024) 67: 6064-6080 [PMID:38595098] |
| GtoPdb | Inhibition of PRMT5 determined by an SDMA in-cell western assay in the HAP1 MTAP-isogenic cell line | - | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2024) 67: 6064-6080 [PMID:38595098] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
