K02288 [Ligand Id: 13266] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1230714 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| ChEMBL | Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2014) 57: 7900-7915 [PMID:25101911] |
| ChEMBL | Inhibition of GST-tagged human recombinant ALK2 (145 to 509 residues) expressed in baculovirus expression system using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis | B | 8.96 | pIC50 | 1.1 | nM | IC50 | Bioorg Med Chem Lett (2022) 55: 128452-128452 [PMID:34780900] |
| GtoPdb | - | - | 8.96 | pIC50 | 1.1 | nM | IC50 | Bioorg Med Chem Lett (2022) 55: 128452 [PMID:34780900] |
| bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| GtoPdb | - | - | 7.46 | pIC50 | 34.3 | nM | IC50 | Bioorg Med Chem Lett (2022) 55: 128452 [PMID:34780900] |
| ChEMBL | Inhibition of GST-tagged human recombinant ALK3 expressed in insect cells using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis | B | 7.46 | pIC50 | 34.3 | nM | IC50 | Bioorg Med Chem Lett (2022) 55: 128452-128452 [PMID:34780900] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assay | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2014) 57: 7900-7915 [PMID:25101911] |
| ChEMBL | Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2014) 57: 7900-7915 [PMID:25101911] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
