ChEMBL ligand: CHEMBL5191392
caseinolytic mitochondrial matrix peptidase proteolytic subunit/ATP-dependent Clp protease proteolytic subunit, mitochondrial in Human [ChEMBL: CHEMBL4523305] [GtoPdb: 3273] [UniProtKB: Q16740] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
caseinolytic mitochondrial matrix peptidase proteolytic subunit/ATP-dependent Clp protease proteolytic subunit, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523305] [GtoPdb: 3273] [UniProtKB: Q16740]
ChEMBL	Binding affinity to human CLpP assessed as dissociation constant by ITC method	B	6.74	pKd	180	nM	Kd	J Med Chem (2022) 65: 7629-7655 [PMID:35609303]
ChEMBL	Agonist activity at human CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate incubated for 10 mins by fluorescence based assay	B	6.7	pEC50	200	nM	EC50	J Med Chem (2022) 65: 7629-7655 [PMID:35609303]
GtoPdb	-	-	6.7	pEC50	200	nM	EC50	J Med Chem (2022) 65: 7629-7655 [PMID:35609303]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]