KU0058948 [Ligand Id: 13125] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL380648 (KU-0058948) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874] | ||||||||
| GtoPdb | Binding affinity determined by isothermal titration calorimetry. | - | 7.72 | pKd | 19 | nM | Kd | J Med Chem (2009) 52: 3108-11 [PMID:19354255] |
| ChEMBL | Binding affinity to human PARP1 by isothermal titration colorimetry | B | 7.72 | pKd | 19 | nM | Kd | J Med Chem (2009) 52: 3108-3111 [PMID:19354255] |
| ChEMBL | Inhibitory activity against PARP1 | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1040-1044 [PMID:16290932] |
| ChEMBL | Inhibition of PARP1 by flashplate scintillation proximity assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 6581-6591 [PMID:18800822] |
| ChEMBL | Inhibition of human PARP1 | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2009) 52: 3108-3111 [PMID:19354255] |
| poly (ADP-ribose) polymerase 3/Poly [ADP-ribose] polymerase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5083] [GtoPdb: 2864] [UniProtKB: Q9Y6F1] | ||||||||
| GtoPdb | Binding affinity for PARP3 catalytic domain (178−532) determined by isothermal titration calorimetry. | - | 7.15 | pKd | 70 | nM | Kd | J Med Chem (2009) 52: 3108-11 [PMID:19354255] |
| ChEMBL | Binding affinity to human PARP3 PARP domain by isothermal titration colorimetry | B | 7.15 | pKd | 70 | nM | Kd | J Med Chem (2009) 52: 3108-3111 [PMID:19354255] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
