ITK7 [Ligand Id: 13123] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL5191676
  • poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874]
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  • poly(ADP-ribose) polymerase family member 10/Poly [ADP-ribose] polymerase 10 in Human [ChEMBL: CHEMBL2429708] [GtoPdb: 3267] [UniProtKB: Q53GL7]
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  • poly(ADP-ribose) polymerase family member 11/Poly [ADP-ribose] polymerase 11 in Human [ChEMBL: CHEMBL2380189] [GtoPdb: 3268] [UniProtKB: Q9NR21]
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  • poly(ADP-ribose) polymerase family member 14/Poly [ADP-ribose] polymerase 14 in Human [ChEMBL: CHEMBL2176777] [GtoPdb: 3269] [UniProtKB: Q460N5]
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  • poly(ADP-ribose) polymerase family member 15/Poly [ADP-ribose] polymerase 15 in Human [ChEMBL: CHEMBL2176778] [GtoPdb: 3270] [UniProtKB: Q460N3]
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  • poly(ADP-ribose) polymerase 2/Poly [ADP-ribose] polymerase 2 in Human [ChEMBL: CHEMBL5366] [GtoPdb: 2772] [UniProtKB: Q9UGN5]
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  • poly (ADP-ribose) polymerase 3/Poly [ADP-ribose] polymerase 3 in Human [ChEMBL: CHEMBL5083] [GtoPdb: 2864] [UniProtKB: Q9Y6F1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874]
ChEMBL Inhibition of PARP1 (unknown origin) B 4.52 pIC50 >30000 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]
poly(ADP-ribose) polymerase family member 10/Poly [ADP-ribose] polymerase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2429708] [GtoPdb: 3267] [UniProtKB: Q53GL7]
ChEMBL Inhibition of PARP10 (unknown origin) B 5.03 pIC50 9280 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]
poly(ADP-ribose) polymerase family member 11/Poly [ADP-ribose] polymerase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2380189] [GtoPdb: 3268] [UniProtKB: Q9NR21]
GtoPdb - - 7.85 pIC50 14 nM IC50 Cell Chem Biol (2018) 25: 1547-1553.e12 [PMID:30344052]
ChEMBL Inhibition of human full length GFP-tagged PARP11 in human HeLa cells incubated for 3 hrs by chemiluminescence based analysis B 7.85 pIC50 14 nM IC50 Eur J Med Chem (2022) 237: 114362-114362 [PMID:35500474]
ChEMBL Inhibition of PARP11 (unknown origin) B 7.85 pIC50 14 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]
ChEMBL Inhibition of human full length PARP11 expressed in Escherichia coli BL21 (DE3) competent cells B 7.85 pIC50 14 nM IC50 J Med Chem (2023) 66: 1301-1320 [PMID:36598465]
poly(ADP-ribose) polymerase family member 14/Poly [ADP-ribose] polymerase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176777] [GtoPdb: 3269] [UniProtKB: Q460N5]
ChEMBL Inhibition of PARP14 (unknown origin) B 5.54 pIC50 2860 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]
poly(ADP-ribose) polymerase family member 15/Poly [ADP-ribose] polymerase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176778] [GtoPdb: 3270] [UniProtKB: Q460N3]
ChEMBL Inhibition of PARP15 (unknown origin) B 4.52 pIC50 >30000 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]
poly(ADP-ribose) polymerase 2/Poly [ADP-ribose] polymerase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5366] [GtoPdb: 2772] [UniProtKB: Q9UGN5]
ChEMBL Inhibition of PARP2 (unknown origin) B 4.52 pIC50 >30000 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]
poly (ADP-ribose) polymerase 3/Poly [ADP-ribose] polymerase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5083] [GtoPdb: 2864] [UniProtKB: Q9Y6F1]
ChEMBL Inhibition of PARP3 (unknown origin) B 4.52 pIC50 >30000 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]
tankyrase/Tankyrase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271]
ChEMBL Inhibition of TNKS1 (unknown origin) B 4.52 pIC50 >30000 nM IC50 J Med Chem (2022) 65: 7532-7560 [PMID:35608571]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]