atamparib [Ligand Id: 13118] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL5095043 (Atamparib, Rbn 2397, Rbn-2397, RBN-2397, RBN2397) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Mono [ADP-ribose] polymerase PARP16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105981] [UniProtKB: Q8N5Y8] | ||||||||
| ChEMBL | Inhibition of PARP16 (unknown origin) | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874] | ||||||||
| ChEMBL | Inhibition of PARP1 (unknown origin) | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged PARP1 (2 to 1014 end residues) incubated for 1 hr by ELISA assay | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| poly(ADP-ribose) polymerase family member 10/Poly [ADP-ribose] polymerase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2429708] [GtoPdb: 3267] [UniProtKB: Q53GL7] | ||||||||
| ChEMBL | Inhibition of PARP10 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal FLAG-tagged / C-terminal Strep-tagged PARP10 (805 to 1025 end residues) expressed in baculovirus infected Sf9 cells expression system incubated for 1 hr by ELISA assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| poly(ADP-ribose) polymerase family member 11/Poly [ADP-ribose] polymerase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2380189] [GtoPdb: 3268] [UniProtKB: Q9NR21] | ||||||||
| ChEMBL | Inhibition of PARP11 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged / C-terminal His-tagged PARP11 (8 to 338 end residues) expressed in baculovirus infected Sf9 cells expression system incubated for 1 hr by ELISA assay | B | 5.64 | pIC50 | 2281 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| Poly [ADP-ribose] polymerase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2429709] [UniProtKB: Q9H0J9] | ||||||||
| ChEMBL | Inhibition of PARP12 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged PARP12 (500 to 701 end residues) expressed in baculovirus infected Sf9 cells expression system incubated for 1 hr by ELISA assay | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| poly(ADP-ribose) polymerase family member 14/Poly [ADP-ribose] polymerase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176777] [GtoPdb: 3269] [UniProtKB: Q460N5] | ||||||||
| ChEMBL | Inhibition of human recombinant N-terminal 6his-tagged / GST-tagged PARP14 (1470 to 1801 end residues) expressed in baculovirus infected Sf9 cells expression system incubated for 1 hr by ELISA assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| ChEMBL | Inhibition of PARP14 (unknown origin) | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| poly(ADP-ribose) polymerase 2/Poly [ADP-ribose] polymerase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5366] [GtoPdb: 2772] [UniProtKB: Q9UGN5] | ||||||||
| ChEMBL | Inhibition of PARP2 (unknown origin) | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells expression system incubated for 1 hr by ELISA assay | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| poly (ADP-ribose) polymerase 3/Poly [ADP-ribose] polymerase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5083] [GtoPdb: 2864] [UniProtKB: Q9Y6F1] | ||||||||
| ChEMBL | Inhibition of PARP3 (unknown origin) | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| Poly [ADP-ribose] polymerase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6142] [UniProtKB: Q9UKK3] | ||||||||
| ChEMBL | Inhibition of PARP4 (unknown origin) | B | 5.04 | pIC50 | 9200 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| Poly [ADP-ribose] polymerase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2380187] [UniProtKB: Q2NL67] | ||||||||
| ChEMBL | Inhibition of PARP6 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| Poly [ADP-ribose] polymerase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3091262] [UniProtKB: Q8N3A8] | ||||||||
| ChEMBL | Inhibition of PARP8 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| Protein mono-ADP-ribosyltransferase PARP9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295895] [UniProtKB: Q8IXQ6] | ||||||||
| ChEMBL | Inhibition of PARP9 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| tankyrase/Tankyrase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271] | ||||||||
| ChEMBL | Inhibition of TNKS1 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged PARP5a (1001 to 1327 end residues) expressed in baculovirus infected Sf9 cells expression system incubated for 1 hr by ELISA assay | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| tankyrase 2/Tankyrase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2] | ||||||||
| ChEMBL | Inhibition of TNKS2 (unknown origin) | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal GST-tagged PARP5b (667 to 1166 end residues) expressed in baculovirus infected Sf9 cells expression system incubated for 1 hr by ELISA assay | B | 5.46 | pIC50 | 3446 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| TCDD inducible poly(ADP-ribose) polymerase/TCDD-inducible poly [ADP-ribose] polymerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2380188] [GtoPdb: 3266] [UniProtKB: Q7Z3E1] | ||||||||
| ChEMBL | Binding affinity to PARP7 (unknown origin) assessed as dissociation constant | B | 9.66 | pKd | 0.22 | nM | Kd | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| GtoPdb | Binding affinity | - | 9.66 | pKd | 0.22 | nM | Kd | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
| ChEMBL | Inhibition of human recombinant N-terminal FLAG-tagged PARP7 (400 to 657(end) residues) expressed in Sf9 cells | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2023) 66: 14095-14115 [PMID:37843892] |
| ChEMBL | Inhibition of human recombinant N-terminal FLAG tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| ChEMBL | Inhibition of human recombinant N-terminal FLAG-tagged PARP7 (400 to 657 end residues) incubated for 1 hr by ELISA assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2023) 66: 473-490 [PMID:36576395] |
| GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2022) 237: 114362 [PMID:35500474] |
| ChEMBL | Displacement of fluorescent labeled RBN011198 from human NanoLuc-tagged full-length PARP7 expressed in HEK293T cells using NanoGlo substrate incubated for 2 hrs by NanoBRET assay | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2022) 237: 114362-114362 [PMID:35500474] |
| ChEMBL | Inhibition of PARP7 (unknown origin) incubated for 30 mins by TR-FRET assay | B | 8.52 | pIC50 | <3 | nM | IC50 | J Med Chem (2023) 66: 1301-1320 [PMID:36598465] |
| ChEMBL | Inhibition of PARP7 (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2023) 66: 14095-14115 [PMID:37843892] |
| ChEMBL | Inhibition of PARP7 (unknown origin) | B | 8.52 | pIC50 | <3 | nM | IC50 | J Med Chem (2022) 65: 7532-7560 [PMID:35608571] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
