oridonin [Ligand Id: 13088] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1164920 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NLRP3 in Human [GtoPdb: 1770] [UniProtKB: Q96P20] | ||||||||
| GtoPdb | Equilibrium dissociation constant (KD) for oridonin binding to purified GFP-NLRP3. | - | 7.28 | pKd | 52.5 | nM | Kd | Nat Commun (2018) 9: 2550 [PMID:29959312] |
| NLRP3/NACHT, LRR and PYD domains-containing protein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3779755] [GtoPdb: 1770] [UniProtKB: Q8R4B8] | ||||||||
| ChEMBL | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by nigericin addition and measured after 30 mins by ELISA | B | 6.09 | pIC50 | 810 | nM | IC50 | J Med Chem (2021) 64: 13633-13657 [PMID:34506712] |
| ChEMBL | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion preincubated for 3 hrs with LPS and for 30 mins with compound prior to nigericin addition and measured after 30 mins by ELISA | B | 6.09 | pIC50 | 810 | nM | IC50 | Eur J Med Chem (2022) 236: 114357-114357 [PMID:35428012] |
| AKT serine/threonine kinase 1 in Human [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| GtoPdb | - | - | 5.08 | pIC50 | 8400 | nM | IC50 | Mol Cancer Ther (2018) 17: 1540-1553 [PMID:29695636] |
| AKT serine/threonine kinase 2 in Human [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| GtoPdb | - | - | 5.05 | pIC50 | 8900 | nM | IC50 | Mol Cancer Ther (2018) 17: 1540-1553 [PMID:29695636] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
