ML364 [Ligand Id: 13057] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3392741 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ubiquitin specific peptidase 2/Ubiquitin carboxyl-terminal hydrolase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293227] [GtoPdb: 2430] [UniProtKB: O75604] | ||||||||
| GtoPdb | Binding affinity for hUSP2 | - | 5.28 | pKd | 5200 | nM | Kd | Sci Transl Med (2023) 15: eadh7668 [PMID:38055802] |
| ChEMBL | Inhibition of human USP2 using Di-Ub IQF as substrate incubated for 15 mins by K63-2 assay | B | 5.96 | pIC50 | 1100 | nM | IC50 | Eur J Med Chem (2020) 191: 112107-112107 [PMID:32092586] |
| GtoPdb | Inhibition of USP2 de-ubiquitinating activity in vitro | - | 5.96 | pIC50 | 1100 | nM | IC50 | Sci Transl Med (2023) 15: eadh7668 [PMID:38055802] |
| ubiquitin specific peptidase 8/Ubiquitin carboxyl-terminal hydrolase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157854] [GtoPdb: 3209] [UniProtKB: P40818] | ||||||||
| ChEMBL | Inhibition of human USP8 using Di-Ub IQF as substrate incubated for 15 mins by K63-2 assay | B | 6.02 | pIC50 | 950 | nM | IC50 | Eur J Med Chem (2020) 191: 112107-112107 [PMID:32092586] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
