teglicar [Ligand Id: 12976] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1231506 (Teglicar) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carnitine palmitoyltransferase 1A/Carnitine O-palmitoyltransferase 1, liver isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293194] [GtoPdb: 3249] [UniProtKB: P50416] | ||||||||
| ChEMBL | Binding affinity to CPT1 (unknown origin) assessed as inhibition constant | B | 6.44 | pKi | 360 | nM | Ki | Eur J Med Chem (2024) 271: 116408-116408 [PMID:38621327] |
| ChEMBL | Inhibition of human CPT1A | B | 5.98 | pIC50 | 1050 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| ChEMBL | Inhibition of CPT1 (unknown origin) | B | 6.17 | pIC50 | 680 | nM | IC50 | Eur J Med Chem (2024) 271: 116408-116408 [PMID:38621327] |
| Carnitine O-palmitoyltransferase 1, liver isoform in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3858] [UniProtKB: P32198] | ||||||||
| ChEMBL | Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria | B | 4.23 | pIC50 | 58800 | nM | IC50 | J Med Chem (2003) 46: 303-309 [PMID:12519067] |
| carnitine palmitoyltransferase 1B/Carnitine O-palmitoyltransferase 1, muscle isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2216739] [GtoPdb: 3250] [UniProtKB: Q92523] | ||||||||
| ChEMBL | Inhibition of human CPT1B | B | 5.27 | pIC50 | 5400 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| Carnitine O-palmitoyltransferase 1, muscle isoform in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3216] [UniProtKB: Q63704] | ||||||||
| ChEMBL | Maximal inhibition of rat CPT1A | B | 5.84 | pIC50 | 1450 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| carnitine palmitoyltransferase 2/Carnitine O-palmitoyltransferase 2, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3238] [GtoPdb: 3252] [UniProtKB: P23786] | ||||||||
| ChEMBL | Inhibition of human CPT2 | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| carnitine palmitoyltransferase 2/Carnitine O-palmitoyltransferase 2, mitochondrial in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4037] [GtoPdb: 3252] [UniProtKB: P18886] | ||||||||
| ChEMBL | Inhibition of rat CPT2 | B | 6.42 | pIC50 | 380 | nM | IC50 | J Med Chem (2011) 54: 3109-3152 [PMID:21504156] |
| GtoPdb | - | - | 6.62 | pIC50 | 240 | nM | IC50 | Structure (2006) 14: 713-23 [PMID:16615913] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
