FHQC [Ligand Id: 12859] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4448591 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843] | ||||||||
| GtoPdb | - | - | 5.65 | pEC50 | 2239 | nM | EC50 | Mol Pharmacol (2014) 86: 200-10 [PMID:24870406] |
| ChEMBL | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry | F | 5.65 | pEC50 | 2238.72 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| ChEMBL | Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay | F | 6.27 | pEC50 | 537.03 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| ChEMBL | Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay | F | 6.28 | pEC50 | 524.81 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| FFA3 receptor/Free fatty acid receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3309101] [GtoPdb: 227] [UniProtKB: Q3UFD7] | ||||||||
| ChEMBL | Agonist activity at mouse FFA3 receptor | B | 5.42 | pEC50 | 3801.89 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
| FFA3 receptor/Free fatty acid receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886125] [GtoPdb: 227] [UniProtKB: B2GV46] | ||||||||
| ChEMBL | Agonist activity at rat FFA3 receptor | B | 5.87 | pEC50 | 1348.96 | nM | EC50 | J Med Chem (2020) 63: 3577-3595 [PMID:32141297] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
