ChEMBL ligand: CHEMBL399379
Acetyl-CoA carboxylase 1 in Human [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085] There should be some charts here, you may need to enable JavaScript!
Acetyl-CoA carboxylase 2 in Human [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763] There should be some charts here, you may need to enable JavaScript!
ATP citrate lyase/ATP-citrate synthase in Human [ChEMBL: CHEMBL3720] [GtoPdb: 3245] [UniProtKB: P53396] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acetyl-CoA carboxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351] [GtoPdb: 1263] [UniProtKB: Q13085]
ChEMBL	Inhibition of human ACC1	B	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874]
Acetyl-CoA carboxylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4829] [GtoPdb: 1264] [UniProtKB: O00763]
ChEMBL	Inhibition of human ACC2	B	4.92	pIC50	12000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874]
ATP citrate lyase/ATP-citrate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3720] [GtoPdb: 3245] [UniProtKB: P53396]
ChEMBL	Inhibition of ACL (unknown origin)	B	6.3	pIC50	500	nM	IC50	J Nat Prod (2023) 86: 1487-1499 [PMID:37291059]
ChEMBL	Inhibition of ACL (unknown origin) incubated for 30 mins in presence of ATP by luminescence based ADP-Glo kinase assay	B	6.34	pIC50	460	nM	IC50	J Nat Prod (2023) 86: 1251-1260 [PMID:37196240]
ChEMBL	Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate after 60 mins by ADP-Glo luminescence assay	B	6.35	pIC50	442	nM	IC50	Eur J Med Chem (2017) 126: 920-928 [PMID:27997879]
ChEMBL	Inhibition of ATP citrate lyase (unknown origin) using sodium citrate as substrate by ADP-Glo luminescence assay	B	6.42	pIC50	377	nM	IC50	Bioorg Med Chem Lett (2017) 27: 929-935 [PMID:28129980]
ChEMBL	Inhibition of human recombinant ATP-citrate lyase	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-3211 [PMID:17383874]
GtoPdb	-	-	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2007) 17: 3208-11 [PMID:17383874]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]