ChEMBL ligand: CHEMBL3771118
Na+/dicarboxylate cotransporter 1/Solute carrier family 13 member 2 in Human [ChEMBL: CHEMBL3712851] [GtoPdb: 978] [UniProtKB: Q13183] There should be some charts here, you may need to enable JavaScript!
Na+/dicarboxylate cotransporter 3/Solute carrier family 13 member 3 in Human [ChEMBL: CHEMBL3712947] [GtoPdb: 979] [UniProtKB: Q8WWT9] There should be some charts here, you may need to enable JavaScript!
Na+/citrate cotransporter/Solute carrier family 13 member 5 in Human [ChEMBL: CHEMBL3769293] [GtoPdb: 981] [UniProtKB: Q86YT5] Na+/citrate cotransporter/Solute carrier family 13 member 5 in Mouse [ChEMBL: CHEMBL3769294] [GtoPdb: 981] [UniProtKB: Q67BT3] Na+/citrate cotransporter/Solute carrier family 13 member 5 in Rat [ChEMBL: CHEMBL3769295] [GtoPdb: 981] [UniProtKB: Q8CJ44] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Na+/dicarboxylate cotransporter 1/Solute carrier family 13 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3712851] [GtoPdb: 978] [UniProtKB: Q13183]
ChEMBL	Inhibition of NaDC1 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	B	4.88	pIC50	13200	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
ChEMBL	Inhibition of NaDC1 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	B	5	pIC50	10000	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
Na+/dicarboxylate cotransporter 3/Solute carrier family 13 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3712947] [GtoPdb: 979] [UniProtKB: Q8WWT9]
ChEMBL	Inhibition of NaDC3 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	B	4.85	pIC50	14100	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
ChEMBL	Inhibition of NaDC3 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	B	5	pIC50	10000	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
Na+/citrate cotransporter/Solute carrier family 13 member 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769293] [GtoPdb: 981] [UniProtKB: Q86YT5]
ChEMBL	Inhibition of NaCT in human hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method	B	6.1	pIC50	794.33	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
ChEMBL	Inhibition of NaCT in human hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method	B	6.13	pIC50	740	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
GtoPdb	-	-	6.29	pIC50	510	nM	IC50	J Med Chem (2016) 59: 1165-75 [PMID:26734723]
ChEMBL	Inhibition of NaCT (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	B	6.29	pIC50	510	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
ChEMBL	Inhibition of NaCT (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	B	6.3	pIC50	501.19	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
Na+/citrate cotransporter/Solute carrier family 13 member 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769294] [GtoPdb: 981] [UniProtKB: Q67BT3]
ChEMBL	Inhibition of NaCT in mouse hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method	B	6.67	pIC50	213.8	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
ChEMBL	Inhibition of NaCT in mouse hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method	B	6.68	pIC50	210	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
Na+/citrate cotransporter/Solute carrier family 13 member 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769295] [GtoPdb: 981] [UniProtKB: Q8CJ44]
ChEMBL	Inhibition of NaCT in rat hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method	B	6.9	pIC50	125.89	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]
ChEMBL	Inhibition of NaCT in rat hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method	B	6.92	pIC50	120	nM	IC50	J Med Chem (2016) 59: 1165-1175 [PMID:26734723]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]