ChEMBL ligand: CHEMBL1499544
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9] There should be some charts here, you may need to enable JavaScript!
glutathione peroxidase 4/Phospholipid hydroperoxide glutathione peroxidase in Human [ChEMBL: CHEMBL4295754] [GtoPdb: 3239] [UniProtKB: P36969] There should be some charts here, you may need to enable JavaScript!
TEA domain transcription factor 4/YAP1-TEAD4 in Human [ChEMBL: CHEMBL5465250] [GtoPdb: 3243] [UniProtKB: P46937, Q15561] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
ChEMBL	Inhibition of Vps34 (unknown origin)	B	7.6	pIC50	25	nM	IC50	J Med Chem (2020) 63: 10135-10157 [PMID:32324396]
ChEMBL	Inhibition of Vps34 (unknown origin) interaction with PIK3 assessed as reduction in autophagy by increasing LC3 level	B	7.74	pIC50	18	nM	IC50	J Med Chem (2020) 63: 10135-10157 [PMID:32324396]
glutathione peroxidase 4/Phospholipid hydroperoxide glutathione peroxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295754] [GtoPdb: 3239] [UniProtKB: P36969]
ChEMBL	Covalent inhibition of GPX4 (unknown origin) assessed as inhibition constant incubated for 30 to 90 mins in presence of glutathione, glutathione reductase and NADPH by microplate reader analysis	B	4.54	pKi	28860	nM	Ki	J Med Chem (2023) 66: 10036-10059 [PMID:37452764]
GtoPdb	-	-	5.31	pIC50	4850	nM	IC50	J Med Chem (2023) 66: 10036-10059 [PMID:37452764]
ChEMBL	Inhibition of GPX4 (unknown origin) incubated for 1 hrs in presence of glutathione and glutathione reductase by microplate reader analysis	B	5.31	pIC50	4850	nM	IC50	J Med Chem (2023) 66: 10036-10059 [PMID:37452764]
ChEMBL	Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability in presence of ferrostatin-1	B	5.66	pEC50	2200	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127538-127538 [PMID:32920142]
ChEMBL	Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability	B	7.55	pEC50	28	nM	EC50	Bioorg Med Chem Lett (2020) 30: 127538-127538 [PMID:32920142]
TEA domain transcription factor 4/YAP1-TEAD4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL5465250] [GtoPdb: 3243] [UniProtKB: P46937, Q15561]
ChEMBL	Inhibition of GST-tagged TEAD4 (217 to 434 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells/FAM-labelled YAP1 (60 to 99 residues)(unknown origin) protein-protein interaction preincubated for 24 hrs at 4 degree C with TEAD4 followed by fluorescent labelled YAP1 addition by fluorescence polarization assay	B	5.96	pIC50	1100	nM	IC50	RSC Med Chem (2023) 14: 1803-1816 [PMID:37731696]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]