ChEMBL ligand: CHEMBL4752759
epoxide hydrolase 2/Epoxide hydratase in Human [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
epoxide hydrolase 2/Epoxide hydratase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913]
GtoPdb	-	-	10.3	pKi	<0.05	nM	Ki	J Med Chem (2021) 64: 1856-1872 [PMID:33550801]
ChEMBL	Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displacement assay	B	10.3	pKi	<0.05	nM	Ki	Bioorg Med Chem (2020) 28: 115735-115735 [PMID:33007552]
ChEMBL	Binding affinity to purified recombinant human sEH by FRET-displacement assay	B	10.3	pKi	<0.05	nM	Ki	J Med Chem (2021) 64: 1856-1872 [PMID:33550801]
ChEMBL	Inhibition of human recombinant sEH using CMNPC as substrate incubated for 5 mins by fluorescent based assay	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2021) 64: 5429-5446 [PMID:33945278]
ChEMBL	Inhibition of human recombinant sEH	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2022) 65: 13660-13680 [PMID:36222708]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]