ChEMBL ligand: CHEMBL4173974 (Astx 660, Astx-660, Astx660, ASTX-660, ASTX660, Tolinapant)
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] There should be some charts here, you may need to enable JavaScript!
Genome polyprotein in Zika virus [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
ChEMBL	Inhibition of CIAP1 (unknown origin)	B	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2019) 167: 76-95 [PMID:30769242]
ChEMBL	Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrs	B	9.66	pIC50	0.22	nM	IC50	J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
ChEMBL	Inhibition of cIAP1 (unknown origin)	B	9.66	pIC50	0.22	nM	IC50	J Med Chem (2023) 66: 3173-3194 [PMID:36821822]
GtoPdb	Measuring inhibition of intracellular degradation of cIAP1 in MDA-MB-231 cells	-	9.66	pIC50	0.22	nM	IC50	J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
Genome polyprotein in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9]
ChEMBL	Inhibition of Zika virus NS2B-NS3 protease	B	6.1	pKi	800	nM	Ki	Bioorg Med Chem Lett (2020) 30: 126965-126965 [PMID:31980339]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHOK1 cells incubated for 600 secs at -80 mV holding potential by automated patch clamp assay	B	4.16	pIC50	69000	nM	IC50	J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL	Inhibition of XIAP (unknown origin)	B	7.4	pIC50	<40	nM	IC50	Eur J Med Chem (2019) 167: 76-95 [PMID:30769242]
GtoPdb	Determined in a cellular XIAP-caspase 9 immunoprecipitation assay	-	8.55	pIC50	2.8	nM	IC50	J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
ChEMBL	Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by immunoprecipitation assay	B	8.55	pIC50	2.8	nM	IC50	J Med Chem (2018) 61: 7314-7329 [PMID:30091600]
ChEMBL	Inhibition of XIAP (unknown origin)	B	8.55	pIC50	2.8	nM	IC50	J Med Chem (2023) 66: 3173-3194 [PMID:36821822]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]