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ChEMBL ligand: CHEMBL4442295 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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GPR6/G-protein coupled receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714130] [GtoPdb: 85] [UniProtKB: P46095] | ||||||||
GtoPdb | Inhibition of GPR6 constitutive cAMP activity in CHO-K1 cells. | - | 7.1 | pEC50 | 79.4 | nM | EC50 | WO2018183145A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (2018) |
ChEMBL | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay | F | 7.1 | pEC50 | 79.43 | nM | EC50 | WO-2018183145-A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (2018) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]