relutrigine [Ligand Id: 12643] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| Nav1.1 in Human [GtoPdb: 578] [UniProtKB: P35498] | ||||||||
| GtoPdb | - | - | 6.96 | pIC50 | 109 | nM | IC50 | Epilepsia (2022) 63: 697-708 [PMID:35037706] |
| Nav1.2 in Human [GtoPdb: 579] [UniProtKB: Q99250] | ||||||||
| GtoPdb | - | - | 6.76 | pIC50 | 172 | nM | IC50 | Epilepsia (2022) 63: 697-708 [PMID:35037706] |
| Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| GtoPdb | - | - | 6.76 | pIC50 | 172 | nM | IC50 | Epilepsia (2022) 63: 697-708 [PMID:35037706] |
| Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0] | ||||||||
| GtoPdb | Inhibition of ATX-II-induced sodium current in hNaV1-6-expressing HEK-293 cells by patch clamp electrophysiology. | - | 6.85 | pIC50 | 141 | nM | IC50 | Epilepsia (2022) 63: 697-708 [PMID:35037706] |
| Nav1.6 in Mouse [GtoPdb: 583] [UniProtKB: Q9WTU3] | ||||||||
| GtoPdb | - | - | 6.84 | pIC50 | 145 | nM | IC50 | Epilepsia (2022) 63: 697-708 [PMID:35037706] |
| Nav1.6 in Rat [GtoPdb: 583] [UniProtKB: O88420] | ||||||||
| GtoPdb | - | - | 6.74 | pIC50 | 180 | nM | IC50 | Epilepsia (2022) 63: 697-708 [PMID:35037706] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
