JB 98064 [Ligand Id: 1262] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL80582
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
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  • H3 receptor in Human [GtoPdb: 264] [UniProtKB: Q9Y5N1]
  • H3 receptor in Rat [GtoPdb: 264] [UniProtKB: Q9QYN8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Histamine H3 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5076] [UniProtKB: Q9JI35]
ChEMBL Binding affinity to guinea pig histamine H3 receptor B 8.7 pKi 2 nM Ki Bioorg Med Chem Lett (2009) 19: 903-907 [PMID:19119007]
ChEMBL In vitro binding affinity for histamine H3 receptor was determined in guinea-pig cerebral cortex using [3H](R)-alpha-methylhistamine B 8.7 pKi 2 nM Ki J Med Chem (2000) 43: 2362-2370 [PMID:10882362]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL Sigma-1 binding assay was performed using [3H](+)-pentazocine to label sigma-1 binding sites, in guinea pig cerebral cortex B 6.59 pKi 257.04 nM Ki J Med Chem (2000) 43: 2362-2370 [PMID:10882362]
H3 receptor in Human [GtoPdb: 264] [UniProtKB: Q9Y5N1]
GtoPdb - - 7.3 pKi - - - Eur J Pharmacol (2002) 453: 33-41 [PMID:12393057]
H3 receptor in Rat [GtoPdb: 264] [UniProtKB: Q9QYN8]
GtoPdb - - 7 pKi - - - Eur J Pharmacol (2002) 453: 33-41 [PMID:12393057]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]