NVP-DKY709 [Ligand Id: 12583] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL5077506
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  • Eukaryotic peptide chain release factor GTP-binding subunit ERF3A in Human [ChEMBL: CHEMBL4523593] [UniProtKB: P15170]
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  • cereblon in Human [GtoPdb: 3086] [UniProtKB: Q96SW2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA-binding protein Ikaros in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4739685] [UniProtKB: Q13422]
ChEMBL Induction of IKZF1 degradation in human GripTite 293 MSR cells assessed as reduction in IKZF1 level measured by PathHunter assay B 4.3 pEC50 >50000 nM EC50 US-20210309638-A1. 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof (2021)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523593] [UniProtKB: P15170]
ChEMBL Induction of GSPT1 degradation in human GripTite 293 MSR cells assessed as reduction in GSPT1 level measured by PathHunter assay B 4.3 pEC50 >50000 nM EC50 US-20210309638-A1. 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof (2021)
cereblon in Human [GtoPdb: 3086] [UniProtKB: Q96SW2]
GtoPdb CRBN binding - 6.89 pIC50 130 nM IC50 Cell Chem Biol (2023) 30: 235-247.e12 [PMID:36863346]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]