compound 15 [PMID: 33738061] [Ligand Id: 12573] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4748198 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453] | ||||||||
| ChEMBL | Binding affinity to recombinant human S1P1 receptor expressed in Chem-1 cell membrane by 33P-SIP binding assay | B | 5.3 | pKi | >5000 | nM | Ki | ACS Med Chem Lett (2021) 12: 351-355 [PMID:33738061] |
| S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228] | ||||||||
| ChEMBL | Binding affinity to recombinant human S1P5 receptor expressed in Chem-1 cell membrane by 33P-SIP binding assay | B | 8.36 | pKi | 4.4 | nM | Ki | ACS Med Chem Lett (2021) 12: 351-355 [PMID:33738061] |
| GtoPdb | - | - | 10 | pIC50 | 0.1 | nM | IC50 | ACS Med Chem Lett (2021) 12: 351-355 [PMID:33738061] |
| ChEMBL | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay | F | 10 | pEC50 | 0.1 | nM | EC50 | ACS Med Chem Lett (2021) 12: 351-355 [PMID:33738061] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
