(-)-Epicatechin [Ligand Id: 12497] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL583912 ((-)-epi catechin, (-)-epicatechin, Epi-catechin, Epicatechin, (-)-epicatechol, Epi-catechol, Epicatechol, L-acacatechin, L-epicatechin, NSC-81161) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibition of aldose reductase in rat lens homogenate | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Nat Prod (2003) 66: 1191-1196 [PMID:14510595] |
| synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay | B | 4.52 | pIC50 | 29900 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| ChEMBL | Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
| ChEMBL | Inhibition of amyloid beta (unknown origin) aggregation | B | 5.28 | pIC50 | 5300 | nM | IC50 | Eur J Med Chem (2018) 152: 570-589 [PMID:29763806] |
| BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415] | ||||||||
| ChEMBL | Binding affinity to BCL2 | B | 4 | pKi | >100000 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 19512-19517 [PMID:18040043] |
| ChEMBL | Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay | B | 4 | pKi | >100000 | nM | Ki | Med Chem Res (2010) 19: 817-835 |
| Arginase in Leishmania amazonensis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3108635] [UniProtKB: O96394] | ||||||||
| ChEMBL | Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate by Dixon reciprocal plot analysis | B | 6.7 | pKi | 200 | nM | Ki | J Nat Prod (2014) 77: 392-396 [PMID:24521209] |
| ChEMBL | Inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by colorimetry | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Nat Prod (2014) 77: 392-396 [PMID:24521209] |
| beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] | ||||||||
| ChEMBL | Inhibition of human BACE-1 | B | 5.35 | pIC50 | 4500 | nM | IC50 | Eur J Med Chem (2018) 152: 570-589 [PMID:29763806] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Binding affinity to COX1 in sheep seminal vesicle | B | 4.59 | pKd | 25900 | nM | Kd | J Nat Prod (2004) 67: 1777-1782 [PMID:15568761] |
| ChEMBL | Inhibition of cyclooxygenase activity of COX1 in sheep seminal vesicle in presence of 1 mM phenol by cyclooxygenase assay | B | 4.91 | pIC50 | 12200 | nM | IC50 | J Nat Prod (2004) 67: 1777-1782 [PMID:15568761] |
| ChEMBL | Inhibition of peroxidase activity of COX1 in heep seminal vesicle by TMPD assay | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Nat Prod (2004) 67: 1777-1782 [PMID:15568761] |
| DNA polymerase beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766] | ||||||||
| ChEMBL | Inhibition of lyase activity of rat DNA polymerase beta after 30 mins by deoxyribose phosphate excision assay | B | 4.73 | pIC50 | 18500 | nM | IC50 | J Nat Prod (2004) 67: 1744-1747 [PMID:15497954] |
| DNA repair protein RAD52 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2362978] [UniProtKB: P43351] | ||||||||
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA by FRET assay | B | 5.84 | pIC50 | 1450 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (2018) |
| fatty acid synthase/Fatty acid synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327] | ||||||||
| ChEMBL | Inhibition of FAS | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4738-4742 [PMID:16870425] |
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2763-2767 [PMID:11591519] |
| Nitric-oxide synthase, endothelial in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4802] [UniProtKB: P29473] | ||||||||
| ChEMBL | Activation of eNOS in BCAEC assessed as increase in nitric oxide level after 10 mins by fluorometric analysis | B | 8.7 | pEC50 | 2 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4441-4446 [PMID:23791569] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2006) 69: 826-828 [PMID:16724851] |
| pyruvate kinase M1/2/Pyruvate kinase isozymes M1/M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618] | ||||||||
| ChEMBL | Inhibition of recombinant PKM2 (unknown origin) Asp177, Ser77, Gly52, Gly128 residues | B | 5.88 | pIC50 | 1330 | nM | IC50 | J Med Chem (2022) 65: 1171-1205 [PMID:34726055] |
| xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] | ||||||||
| ChEMBL | Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (1998) 61: 71-76 [PMID:9461655] |
| TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534] | ||||||||
| GtoPdb | - | - | 3.38 | pEC50 | 417700 | nM | EC50 | Biochem Biophys Res Commun (2011) 405: 620-5 [PMID:21272567] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
