N-[3H]methylhistamine [Ligand Id: 1241] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL507 (N-Methylhistamine)
  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
  • H3 receptor in Rat [GtoPdb: 264] [UniProtKB: Q9QYN8]
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  • H4 receptor/Histamine H4 receptor in Human [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
GtoPdb - - 9.1 pKd - - - Mol Pharmacol (2001) 59: 420-6 [PMID:11179434]
ChEMBL Binding affinity to histamine H3 receptor (unknown origin) B 4.7 pKi 20000 nM Ki Bioorg Med Chem Lett (2016) 26: 5263-5266 [PMID:27692832]
H3 receptor in Rat [GtoPdb: 264] [UniProtKB: Q9QYN8]
GtoPdb - - 9.1 pKd - - - J Pharmacol Exp Ther (2000) 293: 771-8 [PMID:10869375]
H4 receptor/Histamine H4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8]
GtoPdb - - 7.8 pKd - - - Mol Pharmacol (2001) 59: 420-6 [PMID:11179434]
ChEMBL Binding affinity to histamine H4 receptor (unknown origin) B 4.96 pKi 11000 nM Ki Bioorg Med Chem Lett (2016) 26: 5263-5266 [PMID:27692832]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]