fulzerasib [Ligand Id: 12393] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5314463 (Fulzerasib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| KRAS in Human [GtoPdb: 2824] [UniProtKB: P01116] | ||||||||
| GtoPdb | HTRF assay detecting repacement of GDP by GTP on the KRASG12C protein catalyzed by SOS1 | - | 7.6 | pIC50 | 25 | nM | IC50 | WO2021083167A1. Substituted heterocyclic fused cyclic compound, preparation method therefor and pharmaceutical use thereof (2021) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
