LY3410738 [Ligand Id: 12340] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| isocitrate dehydrogenase (NADP(+)) 1 in Human [GtoPdb: 2884] [UniProtKB: O75874] | ||||||||
| GtoPdb | Inhibition of WT hIDH1 | - | 6.98 | pIC50 | 105 | nM | IC50 | US11001596B2. 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors (2021) |
| GtoPdb | Inhibition of hIDH1 with R132H mutation | - | 8.2 | pIC50 | 6.27 | nM | IC50 | US11001596B2. 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors (2021) |
| isocitrate dehydrogenase (NADP(+)) 2 in Human [GtoPdb: 2885] [UniProtKB: P48735] | ||||||||
| GtoPdb | Inhibition of WT hIDH2 | - | 6.05 | pIC50 | 884 | nM | IC50 | US11001596B2. 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors (2021) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
