BAY-069 [Ligand Id: 12232] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4551635 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| branched chain amino acid transaminase 2/Branched-chain-amino-acid aminotransferase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616354] [GtoPdb: 2893] [UniProtKB: O15382] | ||||||||
| ChEMBL | Cellular mechanistic assay – BCAA measurement (MDA-MB-231 cells) | B | 6.06 | pIC50 | 874 | nM | IC50 | Data for DCP probe BAY-069 |
| GtoPdb | - | - | 6.82 | pIC50 | 153 | nM | IC50 | J Med Chem (2022) 65: 14366-14390 [PMID:36261130] |
| ChEMBL | Biochemical assay (BCAT2) | B | 6.89 | pIC50 | 130 | nM | IC50 | Data for DCP probe BAY-069 |
| branched chain amino acid transaminase 1/Branched-chain-amino-acid transferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4679] [GtoPdb: 3210] [UniProtKB: P54687] | ||||||||
| ChEMBL | Cellular mechanistic assay – BCAA measurement (U-87-MG cells) | B | 6.45 | pIC50 | 358 | nM | IC50 | Data for DCP probe BAY-069 |
| GtoPdb | - | - | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (2022) 65: 14366-14390 [PMID:36261130] |
| ChEMBL | Biochemical assay (BCAT1) | B | 7.57 | pIC50 | 27 | nM | IC50 | Data for DCP probe BAY-069 |
| Translocator protein/Peripheral-type benzodiazepine receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4552] [GtoPdb: 2879] [UniProtKB: P16257] | ||||||||
| ChEMBL | GPCRScan assay: inhibition of GABA/PBR | B | 7.13 | pKi | 74.19 | nM | Ki | Data for DCP probe BAY-069 |
| GtoPdb | - | - | 7.13 | pKi | 73.3 | nM | Ki | Data for DCP probe BAY-069. www.ebi.ac.uk/chembl |
| ChEMBL | GPCRScan assay: inhibition of GABA/PBR | B | 7.14 | pKi | 73.28 | nM | Ki | Data for DCP probe BAY-069 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
