asnuciclib [Ligand Id: 12074] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2347597 (Asnuciclib, CDKI73, CDKI-73)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750]
ChEMBL Inhibition of human recombinant His6 tagged CDK9/CyclinT1 expressed in Sf21 insect cells after 40 mins by scintillation counting analysis B 8.4 pKi 4 nM Ki J Med Chem (2013) 56: 640-659 [PMID:23301767]
GtoPdb inhibition of CDK9/CyclinT1 expressed in Sf21 insect cells - 8.4 pKi 4 nM Ki J Med Chem (2013) 56: 640-59 [PMID:23301767]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635]
ChEMBL Inhibition of human recombinant His6 tagged CDK1/Cyclin B expressed in Sf21 insect cells after 40 mins by scintillation counting analysis B 8.4 pKi 4 nM Ki J Med Chem (2013) 56: 640-659 [PMID:23301767]
GtoPdb Inhibition of human recombinant His6 tagged CDK1/Cyclin B expressed in Sf21 insect cells - 8.4 pKi 4 nM Ki J Med Chem (2013) 56: 640-59 [PMID:23301767]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396]
GtoPdb Inhibition of human recombinant His6 tagged CDK2/Cyclin A expressed in Sf21 insect cells - 8.52 pKi 3 nM Ki J Med Chem (2013) 56: 640-59 [PMID:23301767]
ChEMBL Inhibition of human recombinant His6 tagged CDK2/Cyclin A expressed in Sf21 insect cells after 40 mins by scintillation counting analysis B 8.52 pKi 3 nM Ki J Med Chem (2013) 56: 640-659 [PMID:23301767]
cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613, P51946]
GtoPdb Inhibuition of CDK7/CyclinH/MAT1 expressed in Sf21 insect cells - 7.04 pKi 91 nM Ki J Med Chem (2013) 56: 640-59 [PMID:23301767]
ChEMBL Inhibition of human recombinant His6 tagged CDK7/CyclinH/MAT1 expressed in Sf21 insect cells after 40 mins by scintillation counting analysis B 7.04 pKi 91 nM Ki J Med Chem (2013) 56: 640-659 [PMID:23301767]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]