asnuciclib [Ligand Id: 12074] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2347597 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| GtoPdb | Inhibition of human recombinant His6 tagged CDK1/Cyclin B expressed in Sf21 insect cells | - | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2013) 56: 640-59 [PMID:23301767] |
| cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| GtoPdb | Inhibition of human recombinant His6 tagged CDK2/Cyclin A expressed in Sf21 insect cells | - | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2013) 56: 640-59 [PMID:23301767] |
| cyclin dependent kinase 7 in Human [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
| GtoPdb | Inhibuition of CDK7/CyclinH/MAT1 expressed in Sf21 insect cells | - | 7.04 | pKi | 91 | nM | Ki | J Med Chem (2013) 56: 640-59 [PMID:23301767] |
| cyclin dependent kinase 9 in Human [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
| GtoPdb | inhibition of CDK9/CyclinT1 expressed in Sf21 insect cells | - | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2013) 56: 640-59 [PMID:23301767] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
