batoprotafib [Ligand Id: 12068] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL4650521 (Batoprotafib, Ptpn11 inhibitor tno155, Shp2 inhibitor tno155, Tno 155, Tno-155, Tno155, TNO-155, TNO155) |
|---|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG by Q-patch assay | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2020) 63: 13578-13594 [PMID:32910655] |
| protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] | ||||||||
| ChEMBL | Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY122 incubated for 30 mins by fluorescence based DIFMUP assay | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2020) 63: 13578-13594 [PMID:32910655] |
| ChEMBL | Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assay | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2020) 63: 13578-13594 [PMID:32910655] |
| ChEMBL | Allosteric inhibition of wild-type human SHP2 (1 to 535 residues) using DiFMUP and 2p-IRS1 peptide as substrates preincubated for 1 hr and followed by substrate addition and measured by microplate reader method | B | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2022) 230: 114106-114106 [PMID:35063735] |
| ChEMBL | Inhibition of SHP (unknown origin) | B | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287] |
| GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2020) 63: 13578-13594 [PMID:32910655] |
| ChEMBL | Inhibition of SHP2 (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2023) 66: 7101-7139 [PMID:37224022] |
| ChEMBL | Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 60 mins followed by substrate addition for 30 mins by microplate reader method | B | 8.42 | pIC50 | 3.8 | nM | IC50 | J Med Chem (2022) 65: 6729-6747 [PMID:35447031] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
