HR1405-01 [Ligand Id: 11973] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL441414 (Loxoprofen trans alcohol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibitory activity against recombinant human prostaglandin G/H synthase 1 | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665] |
| ChEMBL | Inhibitory potency against Prostaglandin G/H synthase 1 in human whole blood assay | B | 6.55 | pIC50 | 280 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibitory activity against recombinant human Prostaglandin G/H synthase 2 | B | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665] |
| GtoPdb | - | - | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1201-3 [PMID:14980665] |
| ChEMBL | Inhibitory potency against cyclooxygenase-2 in human whole blood assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
