ChEMBL ligand: CHEMBL441414 (Loxoprofen trans alcohol)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] There should be some charts here, you may need to enable JavaScript!
Cytochrome c oxidase subunit 1 in Human [ChEMBL: CHEMBL6173] [UniProtKB: P00395] There should be some charts here, you may need to enable JavaScript!
Cytochrome c oxidase subunit 2 in Human [ChEMBL: CHEMBL6174] [UniProtKB: P00403] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibitory activity against recombinant human prostaglandin G/H synthase 1	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665]
ChEMBL	Inhibitory potency against Prostaglandin G/H synthase 1 in human whole blood assay	B	6.55	pIC50	280	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibitory activity against recombinant human Prostaglandin G/H synthase 2	B	6.41	pIC50	390	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665]
GtoPdb	-	-	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1201-3 [PMID:14980665]
ChEMBL	Inhibitory potency against cyclooxygenase-2 in human whole blood assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1201-1203 [PMID:14980665]
Cytochrome c oxidase subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6173] [UniProtKB: P00395]
ChEMBL	Inhibition of human recombinant COX-1 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate addition	B	5.83	pIC50	1470	nM	IC50	Eur J Med Chem (2022) 235: 114258-114258 [PMID:35339101]
ChEMBL	Inhibition of human recombinant COX-1 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after 5 mins	B	6.3	pIC50	500	nM	IC50	Eur J Med Chem (2022) 235: 114258-114258 [PMID:35339101]
ChEMBL	Inhibition of COX-1 in human whole blood assessed as reduction in thromboxane B2 production by immunoassay	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2022) 235: 114258-114258 [PMID:35339101]
Cytochrome c oxidase subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6174] [UniProtKB: P00403]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after 5 mins	B	6.41	pIC50	390	nM	IC50	Eur J Med Chem (2022) 235: 114258-114258 [PMID:35339101]
ChEMBL	Inhibition of COX-2 in LPS-stimulated human whole blood assessed as reduction in PGE2 production by immunoassay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2022) 235: 114258-114258 [PMID:35339101]
ChEMBL	Inhibition of human recombinant COX-2 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate addition	B	7.59	pIC50	26	nM	IC50	Eur J Med Chem (2022) 235: 114258-114258 [PMID:35339101]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]