zipalertinib [Ligand Id: 11889] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4650281 (Cln 081, Cln-081, CLN-081, CLN081, TAS-6417, TAS6417, Zipalertinib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| GtoPdb | Inhibition of WT hEGFR in a biochemical enzyme assay | - | 8.1 | pIC50 | 8 | nM | IC50 | Mol Cancer Ther (2018) 17: 1648-1658 [PMID:29748209] |
| GtoPdb | Inhibition of hEGFR with D770_N771insNPG insertion in a biochemical enzyme assay | - | 8.13 | pIC50 | 7.4 | nM | IC50 | Mol Cancer Ther (2018) 17: 1648-1658 [PMID:29748209] |
| GtoPdb | Inhibition of hEGFR with T790M/L858R mutation in a biochemical enzyme assay | - | 8.7 | pIC50 | 2 | nM | IC50 | Mol Cancer Ther (2018) 17: 1648-1658 [PMID:29748209] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
