ChEMBL ligand: CHEMBL179691 (NBI-42902)

Gonadotropin-releasing hormone receptor in Rhesus macaque [ChEMBL: CHEMBL5647] [UniProtKB: Q8SPZ1] GnRH1 receptor/Gonadotropin-releasing hormone receptor in Human [ChEMBL: CHEMBL1855] [GtoPdb: 256] [UniProtKB: P30968] GnRH1 receptor/Gonadotropin-releasing hormone receptor in Rat [ChEMBL: CHEMBL3066] [GtoPdb: 256] [UniProtKB: P30969] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Gonadotropin-releasing hormone receptor in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5647] [UniProtKB: Q8SPZ1]
ChEMBL	Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from monkey GnRH receptor expressed in CHO cells by liquid scintillation counting	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Binding affinity at monkey GnRH receptor	B	8.46	pKi	3.5	nM	Ki	J Med Chem (2008) 51: 3331-3348 [PMID:18419112]
GnRH1 receptor/Gonadotropin-releasing hormone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1855] [GtoPdb: 256] [UniProtKB: P30968]
GtoPdb	-	-	9.7	pKd	-	-	-	Biochem Pharmacol (2006) 72: 838-49 [PMID:16930559]
ChEMBL	Binding affinity for Monkey gonadotropin-releasing hormone receptor	B	8.46	pKi	3.5	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity for Human gonadotropin-releasing hormone receptor	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity for Human gonadotropin-releasing hormone receptor	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity to human GnRHR	B	9.25	pKi	0.56	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3344-3349 [PMID:18442905]
ChEMBL	Binding affinity at human GnRH receptor	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2008) 51: 3331-3348 [PMID:18419112]
ChEMBL	Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting	B	9.25	pKi	0.56	nM	Ki	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Binding affinity towards human gonadotropin-releasing hormone receptor (GNRHR) using GnRH peptide as radioligand	B	9.25	pKi	0.56	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2519-2522 [PMID:15863308]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118N	B	5.28	pIC50	5200	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24A	B	5.3	pIC50	5030	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24T	B	5.3	pIC50	5000	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24I	B	5.38	pIC50	4200	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K121A	B	6.01	pIC50	980	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290Q	B	6.58	pIC50	262	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290L	B	6.74	pIC50	182	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284L	B	6.91	pIC50	123	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 20 nM GnRH-induced NFAT activation pre-incubated for 1 hr before GnRH stimulation and measured after 6 hrs by luciferase reporter gene assay	B	7.06	pIC50	87	nM	IC50	J Med Chem (2016) 59: 9150-9172 [PMID:27608177]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300K	B	7.1	pIC50	80	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208D	B	7.37	pIC50	42.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300A	B	7.62	pIC50	24.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F313L	B	7.82	pIC50	15.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y283F	B	7.86	pIC50	13.9	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306K	B	7.94	pIC50	11.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208E	B	8.04	pIC50	9.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300V	B	8.05	pIC50	8.9	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203P	B	8.1	pIC50	8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27E	B	8.12	pIC50	7.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309Q	B	8.18	pIC50	6.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293K	B	8.24	pIC50	5.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR W280F	B	8.26	pIC50	5.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293N	B	8.43	pIC50	3.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293A	B	8.47	pIC50	3.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290F	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR W291F	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S124A	B	8.51	pIC50	3.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Inhibition of Human gonadotropin-releasing hormone receptor stimulated calcium flux	B	8.52	pIC50	3	nM	IC50	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293E	B	8.52	pIC50	3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Antagonist activity at human GnRH receptor expressed in RBL1 cells assessed as inhibition of GnRH-stimulated inositol phosphate production	F	8.55	pIC50	2.8	nM	IC50	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309L	B	8.55	pIC50	2.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K115Q	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306E	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302N	B	8.59	pIC50	2.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27A	B	8.6	pIC50	2.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315A	B	8.62	pIC50	2.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284F	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112F	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302A	B	8.74	pIC50	1.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302Q	B	8.77	pIC50	1.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186K	B	8.77	pIC50	1.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295Q	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305K	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR T190K	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F272L	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112A	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168I	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315D	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295K	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203E	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305D	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111Q	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203Q	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306A	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189E	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118A	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L117A	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189P	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR T51A	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR A50T	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112K	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186D	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295A	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168A	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K191E	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189K	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189A	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203K	B	9	pIC50	1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305A	B	9	pIC50	1	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from human wild type GnRHR	B	9.05	pIC50	0.9	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111A	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111K	B	9.15	pIC50	0.7	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182E	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
ChEMBL	Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cells after 1 hr by microbeta scintillation counting method	B	9.23	pIC50	0.59	nM	IC50	Eur J Med Chem (2018) 145: 413-424 [PMID:29335207]
ChEMBL	Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assay	B	9.23	pIC50	0.59	nM	IC50	J Med Chem (2016) 59: 9150-9172 [PMID:27608177]
ChEMBL	Displacement of [125I]-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182A	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2006) 49: 637-647 [PMID:16420049]
GnRH1 receptor/Gonadotropin-releasing hormone receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3066] [GtoPdb: 256] [UniProtKB: P30969]
ChEMBL	Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from rat GnRH receptor expressed in CHO cells by liquid scintillation counting	B	5.21	pKi	6100	nM	Ki	J Med Chem (2008) 51: 7478-7485 [PMID:19006286]
ChEMBL	Binding affinity for rat gonadotropin-releasing hormone receptor	B	5.52	pKi	3000	nM	Ki	J Med Chem (2005) 48: 1169-1178 [PMID:15715483]
ChEMBL	Binding affinity at rat GnRH receptor	B	5.52	pKi	3000	nM	Ki	J Med Chem (2008) 51: 3331-3348 [PMID:18419112]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]