tetrandrine [Ligand Id: 11859] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL176045 (NSC-77037) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs | F | 6.54 | pIC50 | 288 | nM | IC50 | J Nat Prod (1999) 62: 59-66 [PMID:9917283] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs | F | 6.59 | pIC50 | 257 | nM | IC50 | J Nat Prod (1999) 62: 59-66 [PMID:9917283] |
| KCa2.2/Small conductance calcium-activated potassium channel protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4469] [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
| GtoPdb | Measuring displacement of [125I]apamin | - | 6.51 | pKi | 306 | nM | Ki | ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826] |
| ChEMBL | Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis | B | 6.51 | pKi | 306 | nM | Ki | ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826] |
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6] | ||||||||
| ChEMBL | Displacement of [125I]apamin from SK3 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis | B | 6.34 | pKi | 461 | nM | Ki | ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826] |
| GtoPdb | Measuring displacement of [125I]apamin | - | 6.34 | pKi | 461 | nM | Ki | ACS Med Chem Lett (2024) 15: 215-220 [PMID:38352826] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
