temocaprilat [Ligand Id: 11737] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL300841 (RNH-5139, RS-5139, Temocaprilat, Temocaprilate, Temocaprilato, Temocapril diacid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | Inhibitory activity against rabbit lung Angiotensin I converting enzyme with 5 mM hippuryl-histidyl-leucine as substrate | B | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (1987) 30: 1984-1991 [PMID:3669006] |
| Angiotensin-converting enzyme in Rabbit [GtoPdb: 1613] | ||||||||
| GtoPdb | Inhibition of ACE activity, using hippuryl-histidyl-leucine as substrate, and ACE from rabbit lung. | - | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (1987) 30: 1984-91 [PMID:3669006] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
