gumarontinib [Ligand Id: 11623] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4594400 (Glumetinib, Gumarontinib, Sc-c244, Scc244) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Inhibition of MET (unknown origin) | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2023) 66: 7670-7697 [PMID:37262349] |
| GtoPdb | Inhibition of the kinase activity of purified c-Met using ELISA kinase assay. | - | 9.38 | pIC50 | 0.42 | nM | IC50 | Mol Cancer Ther (2018) 17: 751-762 [PMID:29237805] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
