ChEMBL ligand: CHEMBL3109649
tankyrase/Tankyrase-1 in Human [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271] There should be some charts here, you may need to enable JavaScript!
tankyrase 2/Tankyrase-2 in Human [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
tankyrase/Tankyrase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271]
ChEMBL	Inhibition of human TNKS1 incubated for 30 mins prior to substrate addition measured after 2 hrs by HTRF method	B	6.5	pIC50	316.23	nM	IC50	ACS Med Chem Lett (2014) 5: 10-11 [PMID:24900768]
GtoPdb	-	-	8.4	pIC50	4	nM	IC50	ACS Med Chem Lett (2021) 12: 1005-1010 [PMID:34141085]
tankyrase 2/Tankyrase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2]
ChEMBL	Inhibition of human TNKS2 incubated for 30 mins prior to substrate addition measured after 2 hrs by HTRF method	B	7	pIC50	100	nM	IC50	ACS Med Chem Lett (2014) 5: 10-11 [PMID:24900768]
GtoPdb	-	-	7.2	pIC50	63.1	nM	IC50	ACS Med Chem Lett (2021) 12: 1005-1010 [PMID:34141085]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]