ChEMBL ligand: CHEMBL1438439
RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332] There should be some charts here, you may need to enable JavaScript!
regulator of G-protein signaling 17/Regulator of G-protein signaling 17 in Human [ChEMBL: CHEMBL4295974] [GtoPdb: 2801] [UniProtKB: Q9UGC6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332]
ChEMBL	Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophenylphosphate as substrate for 60 mins by fluorescence analysis	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2016) 26: 87-93 [PMID:26602279]
regulator of G-protein signaling 17/Regulator of G-protein signaling 17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295974] [GtoPdb: 2801] [UniProtKB: Q9UGC6]
ChEMBL	Binding affinity to RGS17 (unknown origin) by ITC assay	B	6.15	pKd	714	nM	Kd	US-20160264616-A1. Therapeutic compounds and methods (2016)
ChEMBL	Inhibition of RGS17 (unknown origin) C117A mutant interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay	B	4.09	pIC50	81800	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of wild type GST-tagged RGS17 (unknown origin) interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay	B	4.33	pIC50	47200	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
GtoPdb	-	-	4.33	pIC50	47200	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of RGS17 (unknown origin) in presence of and ATP Galpha-o by Malachite green steady-state GTPase assay	B	4.45	pIC50	35510	nM	IC50	US-20160264616-A1. Therapeutic compounds and methods (2016)
ChEMBL	Inhibition of RGS17 (unknown origin) GAP activity in presence of GTP by malachite green dye based assay	B	4.46	pIC50	35000	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of RGS17 (unknown origin) assessed as reduction in RGS17 interaction with 6x-his-tagged biotinylated Galpha-o interaction by Alpha-screen assay	B	6.37	pIC50	423.2	nM	IC50	US-20160264616-A1. Therapeutic compounds and methods (2016)

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]