ChEMBL ligand: CHEMBL417799 (Pseudochelerythrine, Sangrovit, Sanguinarin, Sanguinarine)
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
Bcl2-associated agonist of cell death in Human [ChEMBL: CHEMBL3817] [UniProtKB: Q92934] There should be some charts here, you may need to enable JavaScript!
Cell division protein FtsZ in Escherichia coli [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6] There should be some charts here, you may need to enable JavaScript!
butyrylcholinesterase/Cholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] There should be some charts here, you may need to enable JavaScript!
nuclear factor kappa B subunit 1/nuclear factor kappa B subunit 2/RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B complex in Human [ChEMBL: CHEMBL2094258] [GtoPdb: 3281, 3282, 3280] [UniProtKB: P19838, Q00653, Q04206] There should be some charts here, you may need to enable JavaScript!
regulator of G-protein signaling 17/Regulator of G-protein signaling 17 in Human [ChEMBL: CHEMBL4295974] [GtoPdb: 2801] [UniProtKB: Q9UGC6] There should be some charts here, you may need to enable JavaScript!
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method	B	5.91	pIC50	1220	nM	IC50	Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
Bcl2-associated agonist of cell death in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3817] [UniProtKB: Q92934]
ChEMBL	Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assay	B	4.72	pIC50	19000	nM	IC50	J Med Chem (2008) 51: 6699-6710 [PMID:18925736]
Cell division protein FtsZ in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
ChEMBL	Inhibition of Escherichia coli recombinant FTsZ incubated for 10 mins in presence of GTP by spectrofluorimeter analysis	B	5.52	pIC50	3000	nM	IC50	Eur J Med Chem (2020) 190: 112132-112132 [PMID:32066012]
butyrylcholinesterase/Cholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL	Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method	B	5.15	pIC50	7080	nM	IC50	Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
nuclear factor kappa B subunit 1/nuclear factor kappa B subunit 2/RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B complex in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094258] [GtoPdb: 3281, 3282, 3280] [UniProtKB: P19838, Q00653, Q04206]
ChEMBL	Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2014) 22: 3008-3015 [PMID:24775915]
regulator of G-protein signaling 17/Regulator of G-protein signaling 17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295974] [GtoPdb: 2801] [UniProtKB: Q9UGC6]
ChEMBL	Binding affinity to RGS17 (unknown origin) by ITC method	B	6	pKd	1000	nM	Kd	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of RGS17 (unknown origin) C117A mutant interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay	B	4	pIC50	>100000	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of wild type GST-tagged RGS17 (unknown origin) interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay	B	4.14	pIC50	72800	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
GtoPdb	-	-	4.14	pIC50	72800	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of RGS17 (unknown origin) GAP activity in presence of GTP by malachite green dye based assay	B	4.92	pIC50	12000	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL	Antagonist activity at TRPA1 (unknown origin) expressed in HEK293T cells assessed as inhibition of agonist induced channel current by whole-cell patch clamp analysis	B	7.05	pEC50	90	nM	EC50	Eur J Med Chem (2023) 257: 115392-115392 [PMID:37269667]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]