hGCGR antagonist [Ligand Id: 1148] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL179281 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| glucagon receptor/Glucagon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871] | ||||||||
| ChEMBL | Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells | B | 6.74 | pIC50 | 181 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1401-1405 [PMID:15713396] |
| ChEMBL | Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells | F | 6.89 | pIC50 | 129 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1401-1405 [PMID:15713396] |
| GtoPdb | - | - | 7.1 | pIC50 | - | - | - | Diabetes (2004) 53: 3267-73 [PMID:15561959] |
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | Bioorg Med Chem Lett (2005) 15: 1401-5 [PMID:15713396] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
