retigabine derivative 10g [Ligand Id: 11479] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4588394 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
| GtoPdb | - | - | 6 | pEC50 | - | - | - | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
| ChEMBL | Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay | B | 6.11 | pEC50 | 780 | nM | EC50 | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
| Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82] | ||||||||
| ChEMBL | Agonist activity at human KCNQ5 expressed in CHOK1 cells by whole cell patch clamp assay | B | 5.77 | pEC50 | 1680 | nM | EC50 | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
| GtoPdb | - | - | 6 | pEC50 | - | - | - | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
