ChEMBL ligand: CHEMBL3577296
ASIC1/Amiloride-sensitive cation channel 2, neuronal in Human [ChEMBL: CHEMBL1628477] [GtoPdb: 684] [UniProtKB: P78348] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ASIC1/Amiloride-sensitive cation channel 2, neuronal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628477] [GtoPdb: 684] [UniProtKB: P78348]
ChEMBL	Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp assay	B	5.13	pIC50	7340	nM	IC50	J Med Chem (2015) 58: 4449-4461 [PMID:25974655]
GtoPdb	ASIC1a at pH5.0	-	5.2	pIC50	6310	nM	IC50	J Med Chem (2015) 58: 4449-61 [PMID:25974655]
GtoPdb	ASIC1a at pH6.7	-	7.2	pIC50	63	nM	IC50	J Med Chem (2015) 58: 4449-61 [PMID:25974655]
ChEMBL	Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp assay	B	7.56	pIC50	27.35	nM	IC50	J Med Chem (2015) 58: 4449-4461 [PMID:25974655]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]