ChEMBL ligand: CHEMBL3577296
ASIC1/Amiloride-sensitive cation channel 2, neuronal in Human [ChEMBL: CHEMBL1628477] [GtoPdb: 684] [UniProtKB: P78348] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ASIC1/Amiloride-sensitive cation channel 2, neuronal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628477] [GtoPdb: 684] [UniProtKB: P78348]
ChEMBL	Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp assay	B	5.13	pIC50	7340	nM	IC50	J Med Chem (2015) 58: 4449-4461 [PMID:25974655]
GtoPdb	ASIC1a at pH5.0	-	5.2	pIC50	6310	nM	IC50	J Med Chem (2015) 58: 4449-61 [PMID:25974655]
GtoPdb	ASIC1a at pH6.7	-	7.2	pIC50	63	nM	IC50	J Med Chem (2015) 58: 4449-61 [PMID:25974655]
ChEMBL	Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp assay	B	7.56	pIC50	27.35	nM	IC50	J Med Chem (2015) 58: 4449-4461 [PMID:25974655]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]