selepressin [Ligand Id: 11454] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1817709 (Fe-202158, FE 202158, FE-202158, FE202158, Selepressin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| ChEMBL | Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay | F | 5.96 | pEC50 | 1100 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| ChEMBL | Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay | F | 8.62 | pEC50 | 2.4 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| ChEMBL | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay | F | 8.62 | pEC50 | 2.4 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| ChEMBL | Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay | F | 8.62 | pEC50 | 2.4 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| GtoPdb | - | - | 8.62 | pEC50 | 2.4 | nM | EC50 | J Pharmacol Exp Ther (2011) 337: 786-96 [PMID:21411496] |
| V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] | ||||||||
| ChEMBL | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay | F | 9.26 | pEC50 | 0.55 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| ChEMBL | Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay | F | 9.26 | pEC50 | 0.55 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
| ChEMBL | Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay | F | 6.47 | pEC50 | 340 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| ChEMBL | Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay | F | 6.47 | pEC50 | 338.84 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| ChEMBL | Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay | F | 5.57 | pEC50 | 2700 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
| ChEMBL | Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay | F | 5.58 | pEC50 | 2630.27 | nM | EC50 | J Med Chem (2011) 54: 4388-4398 [PMID:21688787] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
