compound 5 [PMID: 19338355] [Ligand Id: 11407] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL523435
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 1/cyclin B1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
Created with Highcharts 10.3.3ValuesChart context menuGlycogen synthase kinase-3 betapKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
Created with Highcharts 10.3.3ValuesChart context menuInhibitor of nuclear factor kappa B kinase alpha subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Chk1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635]
ChEMBL Inhibition of CDK1/Cyclin B B 4.3 pIC50 >50000 nM IC50 J Med Chem (2009) 52: 1853-1863 [PMID:19338355]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of CDK2/Cyclin A B 4.3 pIC50 >50000 nM IC50 J Med Chem (2009) 52: 1853-1863 [PMID:19338355]
ChEMBL Inhibition of CDK2/Cyclin E B 4.3 pIC50 >50000 nM IC50 J Med Chem (2009) 52: 1853-1863 [PMID:19338355]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of human GSK3-beta by scintillation counting B 6.61 pIC50 247 nM IC50 J Med Chem (2009) 52: 1853-1863 [PMID:19338355]
ChEMBL Inhibition of GSK-3beta (unknown origin) B 6.61 pIC50 247 nM IC50 Bioorg Med Chem (2023) 92: 117406-117406 [PMID:37536264]
GtoPdb In a cell-free assay. - 6.61 pIC50 247 nM IC50 J Med Chem (2009) 52: 1853-63 [PMID:19338355]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Inhibition of IKKalpha B 4.3 pIC50 >50000 nM IC50 J Med Chem (2009) 52: 1853-1863 [PMID:19338355]
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Inhibition of CHK1 B 4.3 pIC50 >50000 nM IC50 J Med Chem (2009) 52: 1853-1863 [PMID:19338355]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]