LP533401 [Ligand Id: 11405] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL511275 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| L-Tryptophan hydroxylase 1/Tryptophan 5-hydroxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5689] [GtoPdb: 1241] [UniProtKB: P17752] | ||||||||
| GtoPdb | - | - | 6.23 | pIC50 | 583 | nM | IC50 | J Med Chem (2021) 64: 1037-1053 [PMID:33417443] |
| ChEMBL | Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assay | B | 6.23 | pIC50 | 583 | nM | IC50 | J Med Chem (2021) 64: 1037-1053 [PMID:33417443] |
| L-Tryptophan hydroxylase 1 in Human [GtoPdb: 1241] [UniProtKB: P17752] | ||||||||
| GtoPdb | - | - | 6.23 | pIC50 | 583 | nM | IC50 | J Med Chem (2021) 64: 1037-1053 [PMID:33417443] |
| L-Tryptophan hydroxylase 1/Tryptophan 5-monooxygenase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4809] [GtoPdb: 1241] [UniProtKB: P09810] | ||||||||
| ChEMBL | Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysis | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2014) 57: 4692-4709 [PMID:24844139] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
