LP533401 [Ligand Id: 11405] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL511275 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| L-Tryptophan hydroxylase 1/Tryptophan 5-hydroxylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5689] [GtoPdb: 1241] [UniProtKB: P17752] | ||||||||
| GtoPdb | - | - | 6.23 | pIC50 | 583 | nM | IC50 | J Med Chem (2021) 64: 1037-1053 [PMID:33417443] |
| ChEMBL | Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assay | B | 6.23 | pIC50 | 583 | nM | IC50 | J Med Chem (2021) 64: 1037-1053 [PMID:33417443] |
| L-Tryptophan hydroxylase 1 in Human [GtoPdb: 1241] [UniProtKB: P17752] | ||||||||
| GtoPdb | - | - | 6.23 | pIC50 | 583 | nM | IC50 | J Med Chem (2021) 64: 1037-1053 [PMID:33417443] |
| L-Tryptophan hydroxylase 1/Tryptophan 5-monooxygenase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4809] [GtoPdb: 1241] [UniProtKB: P09810] | ||||||||
| ChEMBL | Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysis | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2014) 57: 4692-4709 [PMID:24844139] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
